Researchers at the University Hospital of Navarra have conducted a study which revealed that people with obesity have high levels of interleukin-32 (both blood and visceral adipose tissue), a molecule that has been associated with increased inflammation, and the development of complications associated with overweight such as hypertension, diabetes, cardiovascular disease and sleep apnea , or various types of cancer, among others.
By reducing interleukin-32 levels in obese people, they may also reduce inflammation and diseases associated with being overweight
The objective of the research that has been published in the scientific journal Diabetes, was to determine which molecules were involved in the inflammatory process that obese patients suffer. As explained Victoria Catalan, specialist of the Department of Endocrinology and clinical nutrition, and member of the CIBEROBN, they wanted to see why people with morbid obesity undergoing Bariatric Surgery, in addition to losing weight, experience a significant improvement in his health.
It is estimated that 80% of the patients that this surgery is performed presents an improvement in diseases such as high blood pressure or diabetes type 2, and also their problems are reduced with other disorders such as osteoarthritis and sleep apnea. In the new study were analyzed data from 90 people, who were classified as thin or obese, and in the second case were divided into diabetics and individuals with normal Glycemic Indexes.
The authors of the work thus identified interleukin-32 as one of the factors involved in inflammation at the molecular level, and that have been pointed out as a possible therapeutic target, because they consider that if they are able to reduce their levels in obese people, they will decrease also inflammation and diseases associated with being overweight, as it is the case with people is that bariatric surgery.